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KMID : 0620920100420080547
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Experimental & Molecular Medicine
2010 Volume.42 No. 8 p.547 ~ p.554
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The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis
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Jung Sun-Do
Park Yoon-Kyung
Shin Jung-Hoon
Lee Hyun-Ji
Kim Soo-Young
Lee Gap-Ryol
Park Se-Ho
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Abstract
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TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.
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KEYWORD
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antigen-presenting cells, antigens, arthritis, CD1d, experimental, immune tolerance, natural
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